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Título: | Origins of diastereoselectivity in mannich additions to 4-substituted piperideines and studies toward enantioselective alternatives |
Autor(es): | SORTO, Jenny Esmeralda Padilla |
Palavras-chave: | Diastereocontrole; Reação de Mannich; Efeito de solvente; Piperideínas |
Data do documento: | 27-Mai-2024 |
Editor: | Universidade Federal de Pernambuco |
Citação: | SORTO, Jenny Esmeralda Padilla. Origins of diastereoselectivity in mannich additions to 4-substituted piperideines and studies toward enantioselective alternatives. 2024. Tese (Doutorado em Química) – Universidade Federal de Pernambuco, Recife, 2024. |
Abstract: | A conventional and simple methodology for the synthesis of cyclic imines was harnessed to prepare three examples of 4-substituted-2,3,4,5-tetrahydropyridines. The prepared piperideines were employed as substrates in a tunable diastereoselective, and chromatography-free Mannich reaction to access structurally novel coumarin-containing N-heterocycles. The transformation was studied experimentally, and a theoretical study was also performed by DFT calculations employing the reaction between 4-methylpiperideine and 4-hydroxycoumarin as a model. Thus, trans-, or cis- configurational isomers were obtained in high purity by solely varying temperature and solvent. The study suggested a Curtin-Hammett behavior, and combined acid catalysis and solvent effect examinations revealed significant mechanistic information by using LSER modeling with Kamlet-Taft solvent polarity empirical scales. Thermodynamic parameters of activation were estimated by experimental data arising from Eyring-type plots. Also, 4-hydroxy-6-methyl-2-pyrone and 5,5-dimethyl-1,3-cyclohexanedione were explored as nucleophiles to explore the scope of the model reaction. Finally, new enantioselective alternatives were tested to obtain these adducts, from which a previously developed EKR step was improved to be proposed as a feasible alternative for their production as pure enantiomers. Other novel N-heterocycles derived from the 4-substituted piperideines such as cyclic enamides and enamines were successfully prepared and analyzed for the enrichment of the present study. |
URI: | https://repositorio.ufpe.br/handle/123456789/57026 |
Aparece nas coleções: | Teses de Doutorado - Química |
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