Production of Lipid Nanoparticles by Microwave Synthesis

Abstract

The present invention describes a simple, quick, economical and sustainable production process for producing lipid nanoparticles using a microwave reactor. The technology of the present invention allows one-pot production of said particles, in one or two steps and in a closed system. Said technology does not use organic solvents or large volumes of water. Said technology allows lipid nanoparticles to be produced for medicinal (therapeutic and/or diagnostic), cosmetic and nutritional purposes. By adjusting the main critical factors of the process, such as time, temperature and stirring efficiency (which are dependent on the dimensions of the magnetic bar, stirring speed and total volume of the formulation), it is possible to produce lipid nanoparticles with the intended features, such as: average size comprised between 30 and 900 nm, preferably between 60 and 300 nm; polydispersion between 0.05 and 0.5, preferably between 0.1 and 0.3; and modular zeta potential value between 10 and 50 mV, preferably between 20 and 40 mV.